Somatic interactions of genomic aberrations in the rrMM data set. (A) Only genomic events with at least 1 significant pairwise association (FDR < 0.1) are shown. (B) Frequency of double-hit events of high-risk features observed in the rrMM data set. (C) Enrichment analysis of double-hit events in rrMM. Each event was compared between rrMM and ndMM cohorts using the Fisher exact test and those significant after multiple-testing correction (FDR < 0.05) are shown with an asterisk.