The translocation (TL) and CNA landscape of rrMM. (A) Circos plot of all IGH-translocated events. Common canonical pairs are annotated. Chromosomes involved in canonical translocations (Chr 4,6,8,11,14,16) are zoomed-in proportionally for better visualization of such events. (B) Circos plot of all IGL-translocated events. Common canonical events are annotated. Chromosomes involved in canonical translocations (Chr 8,11,14, 22) are zoomed-in proportionally for better visualization of such events. (C) Circos plot of all MYC-translocated events. Common canonical events are annotated. Chromosomes involved in canonical translocations (Chr 8,11,14, 22) are zoomed-in proportionally for better visualization of such events. For panels A to C, the color and thickness of the lines connecting the 2 TL breakpoint pairs denote the mean VAF and the prevalence of the TL in this cohort, respectively. Accordingly, thick red lines represent early (ie, high VAF) and frequent TL events in rrMM. (D) Genome-wide landscape of CNA in the form of gain and LOH in the ndMM cohort. The y-axis represents the fraction of samples harboring a particular event at any given chromosomal location. LOH is shown in the opposite direction to the gain events for better visualization. (E) Genome-wide differential landscape of CNA in the form of gain and LOH in the rrMM compared with the ndMM. The y-axis represents the enriched fraction of samples in rrMM harboring a CNA. LOH is shown in the opposite direction to the gain events and depleted events in rrMM are not shown for better visualization. Asterisks denote statistically significant enrichment of common CNA events. (F) Heatmap and dendrogram of enriched CNA at ndMM, LENR, and POMR stages. The rows are the enriched CNA events and columns are the therapeutic stages. Asterisks denote significant positive cline from ndMM to LENR to POMR based on the proportion trend test (FDR < 0.05).