Comutation patterns of DDX41 mutated and unmutated cases with MNs. (A) Frequency of co-occurring driver mutations in DDX41-mutated and unmutated cases. Significant difference (q < 0.1) is shown by an asterisk. (B) Comparison of the frequency of driver mutations between HR-MDS and sAML in DDX41-mutated and -unmutated cases in forest plots of ORs and their 95% CI. Type-1 (FLT3, NRAS, WT1, NPM1, IDH1, IDH2, and PTPN11) and Type-2 (GATA2, KRAS, TP53, RUNX1, STAG2, ASXL1, ZRSR2, and TET2) genes are indicated by red and blue characters, respectively. (C) Compositions of Type-1, Type-2, somatic DDX41, and other mutations are shown for each set of mutations that were newly acquired, that persisted with increased or decreased clone size, and that were lost in the second sampling. (D) Diagonal plot comparing variant allele frequencies adjusted by CNAs (aVAF) of somatic DDX41 mutations (the horizontal axis) and co-occurring driver mutations in other genes indicated by colors (the vertical axis).