Geographic distribution of P/LP germ line variants and somatic mutations in DDX41. (A-C) Disease-specific frequencies of DDX41 variants in different geographical areas including Japan (A), Europe (B), and USA (C). (D) Frequency of truncating germ line variants in DDX41 in the Japanese and European general populations. (E) Geographic distribution of major P/LP germ line DDX41 alleles found in 13 249 cases with MNs (left) is compared with that of somatic DDX41 variants (right). The number of distinct DDX41 alleles/variants (horizontal axis) in each country is shown in color gradient. Highly recurrent major alleles/variants are indicated.