Figure 7.
In vivo hemostatic correction of shRX-platelets by RepSox exposure of developing megakaryocytes. Thrombus formation studies as in Figure 3 with infused shRX-megakaryocytes in a Rose Bengal-photochemical carotid injury model system in NSG/VWFR1326H with NSG mice used as a positive control. To determine in vivo functionalities of infused RepSox-treated shRX-megakaryocytes, we monitored thrombus formation by measuring total blood flow (A) and time to occlusion (B). Mean ± SD are shown. N = 4 to 6 per arm. ∗P ≤ .05, ∗∗P ≤ .01, ∗∗∗P ≤ .001, and ns = not significant by 1-way ANOVA comparing indicated matches.

In vivo hemostatic correction of shRX-platelets by RepSox exposure of developing megakaryocytes. Thrombus formation studies as in Figure 3 with infused shRX-megakaryocytes in a Rose Bengal-photochemical carotid injury model system in NSG/VWFR1326H with NSG mice used as a positive control. To determine in vivo functionalities of infused RepSox-treated shRX-megakaryocytes, we monitored thrombus formation by measuring total blood flow (A) and time to occlusion (B). Mean ± SD are shown. N = 4 to 6 per arm. ∗P ≤ .05, ∗∗P ≤ .01, ∗∗∗P ≤ .001, and ns = not significant by 1-way ANOVA comparing indicated matches.

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