RNA sequencing of BM-infiltrated CD8 T cells from RUX-treated and untreated BMF mice. (A) Heat map of T-cell function−related genes dysregulated in BM-infiltrated CD8⁺ T cells from pooled samples of RUX-treated (n = 3) and untreated BMF (n = 3) control mice. Red−blue color scale depicts gene expression levels (red indicates high, blue low). (B) Top pathways identified by Genomatrix Generanker with the top 300 downregulated genes in BM-infiltrated CD8⁺ T cells from RUX-treated mice, compared to those from untreated BMF control mice. (C) Interferon response, rapamycin-sensitive genes, and Myc gene targets enriched to be downregulated in gene set enrichment plots in CD8⁺ T cells from RUX-treated mice were compared with those from untreated BMF control mice. NES, normalized enrichment score. (D) Putative gene network interactions with the dysregulated genes in CD8⁺ T cells from RUX-treated BMF mice. Pink color represents cell cycle−related genes, and blue represents immune response−related genes.