Summary of AE burden score by treatment arm and subgroup. AE burden score by treatment arm and subgroup for grade 1 to 4 (A) and grade 1 to 5 (B) AEs. P values based on a 2-sided Wilcoxon rank-sum test without adjustment for multiplicity. Lower figures in each panel show a magnification of the 0 to 20 portion of the scale. Acala, acalabrutinib; Ibr, ibrutinib; pts, patients.