Long-term outcomes from the time of systemic treatment. (A) The cumulative incidences of NRM at 6 months were 15.2% (95% CI, 13.3-17.3) and 16.8% (95% CI, 11.8-22.6) in classic and late acute GVHD, respectively (P = .551). (B) The cumulative incidences of relapse at 6 months were 11.6% (95% CI, 9.9-13.5) and 11.9% (95% CI, 7.7-17.0) in classic and late acute GVHD, respectively (P = .869). (C) The probabilities of OS at 6 months were 79.5% (95% CI, 77.1-81.6) in classic and 78.2% (71.5-83.5) in late (P = .827). (D) The cumulative incidences of NRM at 6 months were 11.9% (95% CI, 10.0-14.0) and 30.7% (95% CI, 24.7-37.0) in grades 1/2 and grades 3/4 classic acute GVHD, respectively (P < .001). (E) The cumulative incidences of NRM at 6 months were 8.4% (95% CI, 4.3-14.3) and 32.5% (95% CI, 21.4-44.1) in grades 1/2 and grades 3/4 late acute GVHD, respectively (P < .001).