Study flowchart. Patient disposition and outcome are shown overall and per risk-oriented treatment, by ITT, and as treated. Patients displaying refractory ALL after 2 treatment cycles were off study. Application of allogeneic HCT and chemotherapy based on patient age in the respective risk-oriented therapy cohorts is detailed in Supplemental Table 4; overall, patients aged from 18 to 40 years were more likely to complete the assigned chemotherapy steps, whereas HCT rates did not differ significantly across age groups. CCR, continuous first CR.