Clinical correlates and outcomes of germ line mutations causative of a congenital syndrome or disorder. (A) Forest plot of the ORs for myeloid neoplasm (MN), high-risk MN, moderate-to-severe cytopenia, and pancytopenia in patients harboring germ line mutations identified as causative for a congenital syndrome or disorder (S/D). (B) Forest plot of the ORs for extrahematologic comorbidities, solid tumor(s), familiarity for hematologic/solid tumors (Fam Hem/Solid Tumor), or nonmalignant hematologic disorders (Fam Hem Disorder) in patients with S/D. (C) Forest plot of the HRs for OS, event-free survival, and cumulative incidence of AML or nonleukemic death in patients with S/D receiving a diagnosis of MN. (D) Forest plot of the HRs for OS, event-free survival, and cumulative incidence of MN or nonleukemic death in S/D patients receiving a diagnosis of nonneoplastic disorder. ORs and HRs are shown on a logarithmic scale with 95% confidence interval (CI).