Age distribution at the time of standard hematologic diagnosis in patients with or without germ line mutation. (A) Density curves representing the age distribution at the time of standard diagnosis in patients who are germ line WT in the analyzed genes (gray), patients harboring P/LP mutations identified as causative of a congenital syndrome or disorder (S/D) (red), or carriers of a unique heterozygous mutation in genes associated with autosomal recessive disorders (orange). (B) Box plots showing the median age (horizontal line) and age distribution at the time of diagnosis of MN or nonneoplastic conditions (ICUS/CCUS/AA), in patients who are germ line WT (gray), S/D (red), and carriers (orange). Patients who are germ line mutated were significantly younger at the time of diagnosis of MN than those who are germ line WT (P = .018). (C) Age distribution at the time of diagnosis in patients who are germ line WT (gray), carriers of a unique heterozygous mutation in genes associated with autosomal recessive disorders (orange), and patients with DDX41-associated predisposition (red) (top), or with S/D other than DDX41-associated predisposition (red) (bottom). (D) Age distribution based on the germ line S/D (red dots); median age is indicated with a dashed line.