![Molecular glue degraders and proteolysis-targeting chimeras (PROTACs). The figure illustrates the distinct mechanisms by which molecular glue degraders and PROTACs mediate targeted protein degradation. Specific examples of each compound and their respective targets are provided. SJ6986 represents a molecular glue degrader (cereblon E3 ligase modulator [CELMoD]) that selectively degrades G1 to S phase transition 1 (GSPT1) and GSPT2. CK1a, casein kinase 1 alpha; IKZF1/3, Ikaros zinc finger 1/3; POI, protein of interest.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/142/7/10.1182_blood.2023020923/2/blood_bld-2023-020923-c-gr1.jpeg?Expires=1724247827&Signature=xm494NaPLEv9WT-~Jp95wJzJPhoqEqMdNn04oJ9T5UhKS8zKG2TvJ2EZpR-gO1WQe-y3KaInbonls0f7~OayF7xliZydscXi2L4sZ~mtF-A3kyFKFSc8xwMeLT1o0eCDkMKsNXfAa8IyjOu2G3WnEvT-~FIkdEvE1uFe4wEVjGT3mMvv8tQFVbb5BziHJG7iPt-9sWujistszf2kzOSWfVB7FtTI0e6myFcqlnOIE9Fkk-oa7sBXEPXab~zxgIA82X2kiXuUNB15PA1yTMm9b8gIuz1J2PsIGGfzivd1tGxwk0Y1ZsD-Z4L6pwgVQJ~ygSD-73adN2UfYPHsj1i5Cg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Molecular glue degraders and proteolysis-targeting chimeras (PROTACs). The figure illustrates the distinct mechanisms by which molecular glue degraders and PROTACs mediate targeted protein degradation. Specific examples of each compound and their respective targets are provided. SJ6986 represents a molecular glue degrader (cereblon E3 ligase modulator [CELMoD]) that selectively degrades G1 to S phase transition 1 (GSPT1) and GSPT2. CK1a, casein kinase 1 alpha; IKZF1/3, Ikaros zinc finger 1/3; POI, protein of interest.
