Figure 1.
Genetic structure of the ABO gene locus, including long-range PCR (LR-PCR) amplicon locations and positions of the 4 putative ABO∗A1-diagnostic variants. The coordinates above the gene and next to the PCR primers correspond to the reference sequence NG_006669.2 (LRG_792). Chromosomal coordinates of the first base pair of ABO reference gene on the current human genome reference (GRCh38.p13) is provided underneath the gene. Exons 1 to 7 are represented by black arrows, and the coding DNA sequence (CDS; reference transcript NM_020469.3) in red. The locations of the 2 overlapping LR-PCR amplicons (LR1 and LR2) used to amplify the ABO gene are highlighted by the striped area between both amplicons. The positions of the 4 putative ABO∗A1-specific variants found in this study are indicated by their respective rs numbers. For graphical clearness, the ABO gene is shown as reverse complement.

Genetic structure of the ABO gene locus, including long-range PCR (LR-PCR) amplicon locations and positions of the 4 putative ABO∗A1-diagnostic variants. The coordinates above the gene and next to the PCR primers correspond to the reference sequence NG_006669.2 (LRG_792). Chromosomal coordinates of the first base pair of ABO reference gene on the current human genome reference (GRCh38.p13) is provided underneath the gene. Exons 1 to 7 are represented by black arrows, and the coding DNA sequence (CDS; reference transcript NM_020469.3) in red. The locations of the 2 overlapping LR-PCR amplicons (LR1 and LR2) used to amplify the ABO gene are highlighted by the striped area between both amplicons. The positions of the 4 putative ABO∗A1-specific variants found in this study are indicated by their respective rs numbers. For graphical clearness, the ABO gene is shown as reverse complement.

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