Copy number profiles from Waldenström's macroglobulinemia. Cumulative copy number profiles across samples with (A) IgM MGUS or symptomatic precursor WM, and (B) symptomatic and treatment-exposed Waldenström's macroglobulinemia. Samples from patients with asymptomatic disease that later progressed were considered together with samples from symptomatic patients. In (A/B), red, gain; blue, deletion. ∗ = peak is significantly different between group according to GISTIC analysis. (C) Heatmap of mutations according to clinical stage. (D) Heatmap of copy number and structural variants according to clinical stage.