Categories of relapse phenotype and overall outcomes following relapse. (A) Categories of relapse phenotype. (B) CONSORT flow diagram. Figure made using BioRender. Unknown relapse category due to unavailable immunophenotype at time or relapse. ∗Includes 2 patients who had rapid emergence of LS at first restaging timepoint. (C) Overall survival following relapse (n = 166). Median OS was 11.9 months (95% CI, 9.0-17.0). The 6-, 12-, and 24-month OS rates were 69.8% (95% CI, 62.0% to 76.3%), 49.4% (95% CI, 41.1% to 57.2%), and 34.0% (95% CI, 25.7% to 42.5%), respectively.