Rates of aGVHD and cGVHD among patients with or without HHMs. (A-F) The rates of GVHD are given for (A) aGVHD of all stages, (B) severe aGVHD, (C) aGVHD grades, (D) severe acute gastrointestinal (GI) GVHD, (E) cGVHD of all stages, and (F) moderate to severe cGVHD. Severe acute GVHD is defined as GVHD stage 3 to 4.¹³ Chronic GVHD is staged based on 2014 NIH criteria.¹⁴ (G-H) Multivariable logistic regression analysis of predictors for (G) aGVHD of all stages, and (H) for stages II-IV. CR, complete remission; haplo/cord: haplo-identical/umbilical cord HCT; HCT, hematopoietic cell transplant; LP, likely pathogenic; MAC, myeloablative conditioning; MRD, matched related donor; MUD, matched unrelated donor; OR, odds ratio; RIC, reduced-intensity conditioning.