Proportion of responders and change in SF since the start of deferiprone treatment (ITT population). A responder was defined as a patient who showed a ≥20% decline from baseline in SF. Mean (SD) SF at baseline was 3894 (2591) μg/L. ^aOnly patients who received deferiprone in FIRST and continued deferiprone in FIRST-EXT. ^bOne-sample t test. max, maximum; min, minimum; ITT, intent-to-treat; SF, serum ferritin; SD, standard deviation.