Effect of drug combination on anemic baboons. (A) Effect on absolute reticulocyte counts in PA 9194 (solid line) and PA 9254 (dashed line). (B) Effect on HbF (γ/γ + β). (C) HPLC chromatograms showing the increase in HbF observed after the administration of 1 cycle and 2 cycles of the drug combination in PA 9254 (top row) and PA 9194 (bottom row). (D) Flow cytometry data showing levels of F-cells pretreatment after 1 cycle and 2 cycles of drug administration in PA 9254 (top row) and PA 9194 (bottom row).