Geographic distribution and treatment outcomes of adults with AML with respect to SDI assignments, race, and genetic-risk profile. (A) Map of the United States with light-green to dark-green color scale indicating the calculated SDI based on patients’ home zip code. Dark color corresponds to lower SDI score. (B) OS of patients with AML aged <60 years with respect to their SDI grouping (high vs low). (C) Forest plot depicting final multivariable model for OS. (D) OS of patients with AML belonging to the favorable genetic-risk group of the 2017 European LeukemiaNet classification, comparing patients with high SDI with those with low SDI. (E) OS of high- vs low-SDI groups of patients with AML with respect to the patients’ self-reported race. Only 3 Black patients belonged to the low-SDI group and are not depicted in the graphic.