Fetal liver–derived TP53^R248Q/+ murine erythroblasts retrovirally transduced with the NFIA-ETO2 fusion and transplanted into recipients induces a highly penetrant, transplantable erythroleukemia. By contrast, expressing NFIA-ETO2 in other genetic contexts (wild-type or Tp53^+/− mutant cells) and transducing TP53^R248Q/+ mutant cells with the control vector did not cause leukemia. Ctrl, control; FL, fetal liver; WT, wild type. Professional illustration by Somersault18:24.