MM cell-derived mtDAMPs/mtDNAs levels are elevated in the BM as well as in the peripheral blood. They activate macrophages via the cGAS/cGAMP/STING pathway, which stimulates production and secretion of cytokines (eg, CCL5, CXCL2, CXCL10) leading to tumor cell retention within the BM microenvironment and tumor growth. PB, peripheral blood. The image was generated using BioRender.