Platelet migration on fibrinogen surfaces measured ex vivo, after derivatization of albumin-coated matrices. The formation of lamellipodia is accomplished through the integrin receptor GPIIbIIIa. Fibrinogen binding to GPIIbIIIa triggers an outside-in signaling mediated by the kinases c-Src and 14-3-3ζ through the Gα₁₃ that results in the reorganization of actin cytoskeleton and subsequent platelet migration. Dasatinib, a kinase inhibitor therapeutically used to treat chronic myeloid leukemia, inhibits platelet migration and is therefore associated with hemorrhage events observed during the treatment of leukemia patients. Professional illustration by Somersault18:24.