Transcriptomic changes associated with venetoclax progression in patients with loss(8p). (A) Normalized counts from RNA-seq data for the top 25 genes transcribed from chromosome 8p, based on mean difference in pre- and postvenetoclax progression in samples of the loss(8p) cohort (CLL1, CLL2, CLL4, and CLL9). (B) Volcano plot showing differentially expressed genes from RNA-seq data comparing samples from patients with or without loss(8p). The log₂FC is plotted on the x-axis, and the negative-log₁₀ adjusted P value (using FDR) is plotted on the y-axis. Genes marked in red show differentially expressed genes with an absolute value of log2 (FC) no less than 1 (FC = 2) and adjusted P value < .05.