CN and mutational landscape of pediatric PTLD-DLBCL and comparison with previously published series. Comparison between pediatric PTLD-DLBCL, pediatric and young adult IMC-DLBCL,9 and adult PTLD-DLBCL17,18,21,34 in terms of (A-B) CNA and (C-D) mutational frequencies. The vertical axis of panels A and C represents the number of alterations and the 2 groups are separated in the x-axis (PTLD-DLBCL represented in purple and IMC-DLBCL represented in blue). The asterisk in panel A marks significant differences between both groups according to Wilcoxon rank-sum test P < .05. The vertical axis of panels B,D represents the frequency of alteration (%), with the different CNAs in panel B and genes in panel D represented in the horizontal axis. Asterisks in panel B mark significant differences between adult and pediatric PTLD-DLBCL, according to Fisher exact test P < .1 and in panel D indicate significant differences between adult, either EBV+ or negative, and pediatric PTLD-DLBCL, according to Fisher exact test ∗P < .1 and ∗∗P < .05.
