PFS according to hCKT, iCKT, and CKT. In the CIT arm (A) both, patients with iCKT (red curve) and hCKT (dark gray curve) had significantly shorter PFS than patients with nCKT (blue curve). In the pooled venetoclax arms (B), only patients with hCKT (dark gray curve) but not iCKT (red curve) had shorter PFS than patients with nCKT. When each treatment arm was analyzed separately (C), the presence of a hCKT (solid lines) was associated with significantly shorter PFS in every individual treatment arm. In the pooled venetoclax arms (D), patients with a CKT that includes trisomy 12 and at least an additional trisomy 18 and/or 19 (dark gray curve) had so far no PFS events, whereas patients with a CKT that does not include trisomy 12 plus trisomy 18 and/or 19 (red curve) have significantly shorter PFS compared with patients with nCKT (blue curve). +12, trisomy 12; +18, trisomy 18; +19, trisomy 19.