The karyotypic landscape of CLL from the GAIA/CLL13 clinical trial, illustrating the heterogeneous spectrum of aberrations. Progression-free survival (PFS) is shown with complex karyotype (CKT) with ≥5 aberrations vs <5 aberrations (upper panel), and CKT with trisomies, vs no CKT vs CKT with no trisomies (lower panel). CI, confidence interval; Cum, cumulative; HR, hazard ratio. Professional illustration by Patrick Lane, ScEYEnce Studios.