Prohibitins directly binding to the eukaryotic translation initiation complex (shown here are the factors eIF4G and eIF4F) promote strong translation initiation, which results in CLL cell proliferation, metabolic rewiring, MYC activity, and other effects (not shown). FL3 directly binds to prohibitins, thereby replacing them from the translation initiation factors. As a consequence, translation initiation is reduced, causing reduced proliferation, metabolic rewiring, and MYC activity in CLL cells.