Genetic and clinical factors associated with response and OS. (A) A summary chart of the study design. (B) Bar plots showing the number of cases with the genetic alterations indicated on the x-axis (bottom) and with the proportion of the cases showing response indicated by color (top). (C) A forest plot showing the result of a multivariable logistic regression analysis for the factors associated with achieving CR with complete data for response analysis (n = 396). Explicative variables included in the multivariable model are high-risk karyotypes (poor and very poor groups based on IPSS-R–based karyotype risk classification), multihit TP53 mutations, and mutations in ASXL1 and STAG2. The x-axis is log10 scaled. CI, confidential interval.