Illustration of the 2 IR and their evolution. (A) At baseline, 1 case harboring metabolic lymph nodes in the right supraclavicular, axillary, and inguinal areas at baseline (blue and red arrows). At C4, a new left inguinal lesion appeared, with an increase in the existing right supraclavicular lesions (blue arrows) while metabolic regression was observed (red arrows), showing an IR2 perthe LYRIC criteria. At C8, no metabolic activity was observed in the supraclavicular, axillary, or inguinal areas, indicating a complete metabolic response while retrospectively setting the PP at C4. (B) At baseline, 1 case harbored metabolic nodes in the left iliac and inguinal areas at baseline (blue and red arrows). At C4, 2 lesions showed increased metabolic uptake in the left iliac and inguinal areas, without morphological modification (blue arrows), whereas metabolic regression was observed in the other lesions (red arrow), showing an IR3 per the LYRIC criteria. At C8, there was an increase of metabolic lesions in the para aortic, left iliac, and left inguinal areas pointing to a “true” progression.