ROC results for the 2-stage diagnostic classifier comparing maximum VAF with binary mutation profiles. (Left) Myeloid malignancy vs no myeloid malignancy. (Right) MDS vs non-MDS malignancy. In blue, maximum VAF mutation profiles. In red, binary mutation profile. Solid lines indicate the median area under the curve (AUC) based on 1000 bootstrap samples. Dashed lines indicate the upper and lower 95% confidence interval of the AUC.