RNA-seq identifies Notch signaling in MM.1S p53-KO cells. (A) A volcano plot demonstrates upregulated (red), downregulated (green), no-change (blue) genes in p53-KO clones (A7, B6 and B12). (B) Top Kyoto Encyclopedia of Genes and Genomes enriched pathways from Novogene analysis in p53-KO cells. (C) Shared pathways among p53-KO clones from NOJAH analysis. Circle size corresponds to the number of genes associated with each pathway (refer to bottom left for scale).