Detection of ctDNA mutations and evolution during zanubrutinib therapy for 5 patients. Represented is the relative abundance for each detected mutation (plotted as hGE/mL plasma, calculated from AF and plasma cfDNA concentration) and variation over time (x-axis: days). Numbers indicated above the plot at the sample time-points are the calculated total ctDNA (hGE/mL plasma). Associated tables present values for all BTK, PLCG2, TNFAIP3, KMT2D, MYD88, NOTCH2 and TP53 mutations. MZ04 not shown as only one time point (D254) was available for analysis. BD = below detection.