Whole genome landscape of SMZL055 at diagnosis and transformation. (A) Circos plots displaying structural variants and CNAs at diagnosis (left) and transformation (right). (B) Representation of the number of mutations shared by (gray), or specific to, the SMZL (green) and SMZL-T (pink) samples. (C) Representation of the reciprocal translocation t(14;19)(q32;q13). (D) Chromosome 15 of the transformation sample with a chromothripsis pattern inactivating B2M gene, acquired at transformation.