Genomic evolution patterns in SMZL-T. (A) Comparison of frequently altered genes in SMZL (left) and SMZL-T (right). Genes are clustered by pathways (in different colors). Only genes with at least 3 alterations in 1 of the groups are depicted. Asterisks indicate the alterations significantly enriched in 1 of the groups. (B) Comparison of CN profiles of 22 patients with SMZL at diagnosis (green) and 27 patients with SMZL-T at transformation (pink). CN gains are depicted in the upper part of plot, and losses at the bottom. CN regions with recurrence of n ≥ 4 are represented.