Inflammatory parameters are increased in patients with AIHA and are unaffected by C1-INH treatment. (A,C) Nucleosome and EA complex levels are increased in patients with AIHA compared with HCs, indicating inflammation and neutrophil activation. (B,D) Nucleosome and EA complexes are unaffected by C1-INH treatment. Data expressed as median + IQR, significance tested using Mann-Whitney test (A,C) and Wilcoxon matched-pairs signed rank test (B,D). ∗P ≤ .05, ∗∗P ≤ .01, ∗∗∗P ≤ .001.