Figure 4.
The Gata1s anemia phenotype is transplantable. (A) Schematic of the experimental design of transplantation of Ly5.2 Gata1s BM to irradiated Ly5.1 recipients. (B) PB chimerism in transplant recipients at different time points after transplantation. Mean ± SD are shown. (C) Graphs depict serial white blood cell (WBC) count, RBC count, Hb, and PLT count in transplant recipients over time. (D) Ly5.1 donor BMCs were transplanted into lethally irradiated WT and G1s Ly5.2 recipient mice. Peripheral chimerism (E) and WBC, RBC, Hb, HCT, and PLT (F) were monitored after transplantation. Mean ± SD are shown, N ≥ 5, age = 2 months. ∗P ≤ .05, ∗∗∗∗P ≤ .0001 by 2-way ANOVA.

The Gata1s anemia phenotype is transplantable. (A) Schematic of the experimental design of transplantation of Ly5.2 Gata1s BM to irradiated Ly5.1 recipients. (B) PB chimerism in transplant recipients at different time points after transplantation. Mean ± SD are shown. (C) Graphs depict serial white blood cell (WBC) count, RBC count, Hb, and PLT count in transplant recipients over time. (D) Ly5.1 donor BMCs were transplanted into lethally irradiated WT and G1s Ly5.2 recipient mice. Peripheral chimerism (E) and WBC, RBC, Hb, HCT, and PLT (F) were monitored after transplantation. Mean ± SD are shown, N ≥ 5, age = 2 months. ∗P ≤ .05, ∗∗∗∗P ≤ .0001 by 2-way ANOVA.

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