Overexpression of CRLF2 and EPOR. (A) Normalized expression (Log2 TPM+1) of CRLF2 in ascending order. Data from 184 BCP-ALLs (144 B-other and 40 classical subtypes of ALL) are shown. Symbols represent different genetic alterations. The dashed box highlights samples with CRLF2 expression three-fold higher than the median, which correspond to samples with CRLF2-rearrangements (P2RY8-CRLF2, IGH-CRLF2) or CRLF2 p.F232C. (B) Normalized rank-ordered expression (Log2 TPM+1) of EPOR. The “outlier” case corresponds to the single IGH-EPOR found by fusion transcript analysis. AJ2E, group of ABL-, JAK2-, and EPOR-fusion cases.