Overview of gene fusions discovered by targeted RNA sequencing. (A) Circos plot showing the gene fusions schematically organized into chromosome position, both for classical and B-other ALL cases. Genes are arranged based on their genomic position in the chromosome (clockwise from chromosome 1 to 22, followed by X and Y). The line links the 2 partner genes in a fusion, and the colored legend shows the rearrangement type. All classical gene fusions are shown as light blue ribbons. (B) Zoomed-in view of fusion genes to show in more detail the rearrangements found specifically in the 144 B-other–classified cases. Ribbon widths are proportional to the frequency of a specific gene in a fusion event. (C) Number of in-frame fusion genes found in 47 of 144 B-other ALL cases. The bars indicate the number of patients in which a given fusion gene was observed. Rare and novel fusion genes discovered in this study are highlighted. ^§PAX5-ZCCHC7 was found in a patient that also has a functional ETV6-RUNX1 fusion. ∗IGH-CRLF2 were detected by high CRLF2 expression and confirmed by FISH. CTX, interchromosome; DEL, deletion; INS, insertion; ITX, intrachromsome.