Comparisons between DS-ALL and non–DS-ALL. (A) Frequencies of genetic subtypes of DS-ALL and non–DS-ALL. (B-C) Comparison of the frequencies of gene alterations in DS-ALL and non–DS-ALL in (B) all the subtypes and (C) CRLF2-r only. A total of 51 genes altered in more than 3% in either DS-ALL or non–DS-ALL data are compared and only genes with nominal P < .05 are shown. Comparisons were also performed within ETV6::RUNX1 and high hyperdiploid subtypes and no gene with Bonferroni corrected P < .05 was identified.