Contribution of lineage-restricted and SO clones. (A) Number of clones found contributing to 1, 2, 3, 4, or 5 lineages. (B) Correlation of the mean normalized abundance of 4-, 3-, 2-, and 1-lineage clones with the number of times the clone was detected across all analyzed samples. Gray background indicates clones associated with other groups. The mean normalized abundance and average number of times detected across all clones are indicated by the green horizontal line and the blue vertical line, respectively. (C) Frequency of SO clones over time.