Figure 4.
Impaired FGF23 cleavage aggravates functional iron deficiency in acute inflammation. Time course of serum (A) iron and (B) TSAT, (C) Hamp mRNA expression in selected organs, (D) liver Hamp mRNA expression, (E) serum hepcidin, and (F) bone marrow Erfe mRNA expression in 6-week-old WT mice, 6 hours after administration of a single dose of 250 ng/g IL-1β. (G) bone marrow Erfe mRNA expression and serum (H) iron and (I) TSAT, (J) liver Hamp mRNA expression and serum (K) hepcidin in 6-week-old WT and Fgf23Dmp1-cKO mice 6 hours after administration of a single dose of 250 ng/g IL-1β. (L) Liver Hamp mRNA expression, serum (M) hepcidin, (N) iron and (O) TSAT in 6-week-old WT and FurinDmp1-cKO mice 6 hours after administration of a single dose of 250 ng/g IL-1β. n ≥ 5 per group. P < .05 vs (∗) Ctr, (a) WT Ctr, (b) cKO Ctr, (c) WT IL-1β.

Impaired FGF23 cleavage aggravates functional iron deficiency in acute inflammation. Time course of serum (A) iron and (B) TSAT, (C) Hamp mRNA expression in selected organs, (D) liver Hamp mRNA expression, (E) serum hepcidin, and (F) bone marrow Erfe mRNA expression in 6-week-old WT mice, 6 hours after administration of a single dose of 250 ng/g IL-1β. (G) bone marrow Erfe mRNA expression and serum (H) iron and (I) TSAT, (J) liver Hamp mRNA expression and serum (K) hepcidin in 6-week-old WT and Fgf23Dmp1-cKO mice 6 hours after administration of a single dose of 250 ng/g IL-1β. (L) Liver Hamp mRNA expression, serum (M) hepcidin, (N) iron and (O) TSAT in 6-week-old WT and FurinDmp1-cKO mice 6 hours after administration of a single dose of 250 ng/g IL-1β. n ≥ 5 per group. P < .05 vs (∗) Ctr, (a) WT Ctr, (b) cKO Ctr, (c) WT IL-1β.

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