American Society of Hematology

Figure 2.

Deletion of Fgf23 in osteocytes reduces circulating FGF23 in acute inflammation. Serum (A) cFGF23, (B) iFGF23, (C) i/cFGF23, (D) phosphate, (E) 1,25OH2D, bone (F) Fgf23 mRNA, and (G) FGF23 protein expression in 6-week-old WT and Fgf23Dmp1-cKO mice 6 hours after administration of a single dose of 250 ng/g IL-1β. n ≥ 5 per group, P < .05 vs (a) WT Ctr, (b) Fgf23Dmp1-cKO Ctr (c) WT IL-1β. (H) Fgf23 mRNA levels and secreted (I) cFGF23 and (J) iFGF23 in primary osteoblast cultures cultured for 3 weeks in osteoblastic medium and treated with saline or 10 ng/mL of IL-1β for 6 hours. n ≥ 3 per group, P < .05 vs (a) WT Ctr, (b) Fgf23Dmp1-cKO Ctr (c) WT IL-1β.

Deletion of Fgf23 in osteocytes reduces circulating FGF23 in acute inflammation. Serum (A) cFGF23, (B) iFGF23, (C) i/cFGF23, (D) phosphate, (E) 1,25OH₂D, bone (F) Fgf23 mRNA, and (G) FGF23 protein expression in 6-week-old WT and Fgf23^Dmp1-cKO mice 6 hours after administration of a single dose of 250 ng/g IL-1β. n ≥ 5 per group, P < .05 vs (a) WT Ctr, (b) Fgf23^Dmp1-cKO Ctr (c) WT IL-1β. (H) Fgf23 mRNA levels and secreted (I) cFGF23 and (J) iFGF23 in primary osteoblast cultures cultured for 3 weeks in osteoblastic medium and treated with saline or 10 ng/mL of IL-1β for 6 hours. n ≥ 3 per group, P < .05 vs (a) WT Ctr, (b) Fgf23^Dmp1-cKO Ctr (c) WT IL-1β.

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