Expression of translation-related genes correlates with disease progression and poor survival in patients with CLL. Gene expression analysis was performed by qRT-PCR for 8 genes involved in translation in a cohort of 144 patients with CLL. The relationship between gene expression and survival was evaluated by Cox univariate regression analysis. Gene expression in clinical groups was evaluated by differential expression analysis for single genes or by logistic regression (LR) analysis for multiple genes. (A,E) Calculated HRs >1 (red dots, P value <.05) indicate an increased risk for patients with high single-gene expression in term of OS (A) and TFS (E). (B,F) Relation between high or low eIF4E2 gene expression and OS (B) or TFS (F). Low and high groups are of identical size (n = 72). (C) Relationship between high or low combined 8-gene expression and OS. (D) Calculated HRs >1 (red dots, P value <.05) indicate an increased risk for patients with high multiple gene expression in term of OS. (G) Standardized expression of single genes in groups of patients based on prognostic markers (CytoG unfav.: cytogenetics unfavorable; group size indicated in each panel). (H-I) Relation between high or low eIF4E2 gene expression and OS in patients with IGHV_UM or LPL⁺ CLL (H), and TFS in patients with Binet A CLL (I). ∗P < .05, ∗∗P < .01, ∗∗∗P < .001.