Figure 3.
Post-alloSCT derived MSC with reduced proliferation show specific differential expression for genes regulating EMT and ECM. (A) Sample similarity distance matrix of RNAseq analysis from Figure 2 in post-alloSCT MSC of patients 1 to 5 (n = 5 with technical duplicates A/B). (B) PDT (over passage 2-5) in pre- and post-alloSCT MSC from patients 1 to 5. (C) Authentication of DGE in post- vs pre-alloSCT MSC according to their differential proliferation, ie, normal proliferation of post-alloSCT MSC from patients 1, 2, and 4 and reduced proliferation in post-alloSCT MSC from patients 3 and 5. (D) GSEA for upregulated genes in post-alloSCT MSC with damaged proliferation, ie, patient 3 and 5.

Post-alloSCT derived MSC with reduced proliferation show specific differential expression for genes regulating EMT and ECM. (A) Sample similarity distance matrix of RNAseq analysis from Figure 2 in post-alloSCT MSC of patients 1 to 5 (n = 5 with technical duplicates A/B). (B) PDT (over passage 2-5) in pre- and post-alloSCT MSC from patients 1 to 5. (C) Authentication of DGE in post- vs pre-alloSCT MSC according to their differential proliferation, ie, normal proliferation of post-alloSCT MSC from patients 1, 2, and 4 and reduced proliferation in post-alloSCT MSC from patients 3 and 5. (D) GSEA for upregulated genes in post-alloSCT MSC with damaged proliferation, ie, patient 3 and 5.

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