Patient clinical courses. (A) Clinical course of case 1 bone marrow evaluation of leukemic blasts by MFC and by NGS of the IGH/IGL gene through clinical course, with MFC diagrams at diagnosis and at LS. (B) Clinical course of case 2 bone marrow evaluation of leukemic blasts by MFC and by NGS of the IGH/IGL gene through clinical course, with histology images at diagnosis, at LS, and at relapse aftertransplant. AML, acute myeloid leukemia; Blina, blinatumomab; DEX, dexamethasone; LOD, level of detection; PEG, pegaspargase; T-APCs, T-cell antigen-presenting cells; Tx, treatment; SSc, side scatter; VCR, vincristine.