Survival curves for all patients receiving CAR-T and patients with CAR-T failure. Survival curves constructed using the Kaplan-Meier method. All curves include 95% CI and censored points are denoted with a mark on the curve. (A) PFS of all patients receiving CD19-directed CAR-T for aggressive B-NHL, from the time of CAR-T infusion. (B) OS of all patients receiving CD19-directed CAR-T for aggressive B-NHL, from the time of CAR-T infusion. (C) OS of all patients with CAR-T failure from time of post–CAR-T progression. (D) PFS of patients with CAR-T failure in patients who received subsequent therapies for aggressive B-NHL, from time of CAR-T progression. (E) OS of patients with CAR-T failure stratified by those who received subsequent therapy post–CAR-T vs those who did not. (F) OS from time of progression post–CAR-T for patients with SD or progressive at day 30 vs all other patients experiencing progression post–CAR-T. CI, confidence intervals; SD, stable disease; Tx, treatment.