Determinants of low HRQoL – univariable analyses. Presented are the univariable analyses of the determinants of low EQ-5D index value and of low EQ-5D VAS score. ORs are colored if P value < .15 and gray if P value > .15. ∗At least 1 unit RBC transfusion for a surveillance time of 8 weeks before the HRQoL assessment; ∗∗Average number of RBC transfusions per month since the last visit or since the MDS diagnosis; ∗∗∗Progression to higher IPSS-R risk group. HCT-CI, hematopoietic cell transplantation-specific comorbidity index; IPSS-R (vs VL/L), all remaining IPSS-R groups vs very low/low risk.