Baseline mutational features of study cohort. (A) Dot plot showing the IDH2 variant allele frequency in each treatment arm. (B) Violin plot showing the frequency of genes mutated per patient in each treatment arm. (C) Complex heatmap of the entire cohort; each column represents a patient. Treatment arm, IPSS-R risk group, cytogenetic risk group, indicated mutations, and response are shown for each patient. Shown to the right of the plot are the percentage of patients in each labeled row. AZA, azacitidine; ENA, enasidenib; NR, not reported; SD, stable disease.