Heat map displaying each patient by histology, age, and gender with each column displaying the chemotherapy dose level achieved by cycle. ∗ indicates that patient had a platelet nadir <25 000 cells per μL requiring dose reduction to DL1. ∗∗ indicates that patient had a grade 3 colonic perforation in the setting of diverticulitis requiring interruption of chemotherapy for surgery. The subsequent cycle was delayed 12 days and dose level decreased to DL1 as discretion of investigator while maintaining the standard Pola dose. ∗∗∗ indicates that patient died of sepsis during cycle 1. F, female; M, male.