In vivo effect of various peptide-decorated particles in VWD-2B and VWF-KO murine models. Mice were injected with control particles, SP nanoparticles or particles decorated with various combinations of peptides (2 mg/kg). Bleeding was measured for 30 minutes (VWD-2B) (A) or 20 minutes (VWF-KO) (B) after amputation of 3 mm of the tail tip. Blood was collected in warm saline and quantified using a hemoglobin calibration curve. Each dot represents an individual mouse. Data are presented as mean ± SD. Statistical analysis was performed using a one-way ANOVA with Dunnett's correction. ∗∗P ≤ .01; ∗∗∗P ≤ .001; ∗∗∗∗P ≤ .0001. SP nanoparticles (3 peptides) are represented with the plain gray bar whereas particles decorated with dual peptides appear in diagonally striped bars and single-decorated particles appear in horizontally striped bars.